FDA Review of Ampligen Happening Right Now at the Arthritis AdvisoryAs I type this I am listening to Dr. Lucinda Bateman followed by Robert Miller, a patient advocate colleague of mine of many years. He is a living proof of how Ampligen works for many ME/CFS patients. The direct link to watch the entire event is:
I am posting below the entire comment by Dr. Kenneth Friedman's to the FDA committee regarding the reasons why Ampligen should be approved by the FDA today. No more waiting! No more excuses! The time is now! ONE VOICE, ONE COMMUNITY, ONE CAUSE (TM).
Submitted December 6, 2012
For the FDA Arthritis Advisory Committee Meeting of December 20, 2012 NDA 22151
|Kenneth Friedman, PhD|
Those of us who have even a glancing knowledge of CFS, know that CFS has been treated like the plague-ridden buttocks of chronic diseases. Neither the National Institutes of Health or the Centers for Disease Control and Prevention (CDC) will conduct a proper epidemiological study to estimate or confirm actual number of patients who have CFS in the United States. Indeed, the CDC, who changes case definitions of the illness apparently on whim, has varied the number of patients from 800,000 to 4 million – a more than fourfold difference – without any concern for the accuracy of its numbers. But upon the assumption that there are 1 million CFS patients in the United States, you would think that the National Institutes of Health (NIH) would have a program dedicated to researching the illness within the walls of at least one of its institutes. Not so. There is not one, research laboratory within the entire NIH studying CFS. And as for the CDC, despite its having a laboratory devoted to CFS research in its Chronic Viral Diseases Branch, there are no recent studies emanating from it dealing with the etiology or pathophysiology of the illness. Hence, our concern is that the FDA is following the lead of its sister agencies of choosing to ignore, or worse, undermine, its responsibilities to CFS patients and those who attempt to assist them.
While the FDA announcement speaks of this application as being “new,” in fact, it is not. The manufacturer of Ampligen, a small pharmaceutical company named Hemispherx, has appeared before the FDA before, only to be turned away and ordered to perform more clinical studies. Without the resources of a large pharmaceutical company, it has conducted clinical trials to the best of its ability in a patient-cost-recovery program. If the object of clinical trials is to prove drug efficacy, the trials have done so: some CFS patients when given Ampligen, improve dramatically. Take their Ampligen away, they relapse. Reinstitute the Ampligen, they improve again. Not all CFS patients improve, but if the CDC can vary its estimate of the number of CFS patients by varying its CFS case definition, the fact that not all patients improve suggests that the case definition of CFS needs to be improved, or that subsets of CFS patients exist, and that Ampligen works on a specific subset or, perhaps, even several subsets.
So why then is the Ampligen application before the Arthritis Advisory Committee? Two possible reasons come to mind: (1) The FDA does not have an advisory committee better equipped to deal with this application, or (2) The prejudice against CFS, its research and its treatment is so large, that the FDA feels that the application would have a less prejudicial review before an irrelevant advisory committee rather than a committee more familiar with CFS. Perhaps, the FDA, like the NIH, does not have an existing advisory committee with the appropriate expertise to competently process CFS applications and considers the formation of such an advisory committee too costly. The National Institutes of Health has been notorious for having inappropriate reviewers sit in judgment of extramural, CFS research applications only to reject those applications for specious reasons generated by ignorance. Institutional and peer prejudice against CFS, CFS research, and the brave investigators who attempt to investigate this illness have been called to this nation’s attention at the NIH, Chronic Fatigue Syndrome State of Knowledge Workshop (http://www.vtcfids.org/images/Elephants%20in%20the%20Room%20As%20Delivered.pdf). The failure of the federal government to act on the deliberate closure of CFS laboratories at universities and the termination of CFS researchers has led to yet another closure of a university research and clinical laboratory dedicated to CFS within recent months - proving the pervasive, poisoned environment for CFS treatment and research within the United States. How could the attitudes and culture which cause and permit universities, literally from coast-to-coast, to close CFS laboratories and prevent their faculties from engaging in CFS-related scholarly activity not infiltrate federal advisory committees?
Quite possibly, the timidity of the FDA to approve the use of Ampligen for CFS patients, as well as its timidity in the approval of a variety of other applications under its consideration, is a response to lessons learned in the past. When the FDA received the application to market thalidomide in the United States, after it had been marketed by 14 pharmaceutical companies in 46 different countries, it was considered to be a rather straightforward application. However, little was known about its side effects, and the drug affected experimental animals differently than humans. The FDA delayed approval. Subsequently, reports from Australia and West Germany indicated that thalidomide was associated with cases of human limb deformities and other congenital abnormalities. The drug was removed from all world markets and the application for approval in the United States was withdrawn. A national health crisis had been averted by stringent and slow adherence to FDA, drug approval rules.
However, subsequent to its initial removal from the market, thalidomide has been shown to be an effective therapeutic agent in leprosy, tuberculosis, sepsis, and cancer. Thalidomide may be useful in
There is no evidence to suggest that Ampligen is a thalidomide. There is no evidence to suggest that are as severe, potential side effects to the use of Ampligen as there are to thalidomide. Yet, for some CFS patients, the consequences of being denied Ampligen therapy are as severe and possibly worse than living with the side effects of thalidomide.2 Some CFS patients without Ampligen have no lives whereas with Ampligen they do. If the FDA can approve thalidomide for patient use in the United States, can there be any reason not to approve Ampligen?
1 http://www.nyu.edu/classes/jaeger/thalidomide.htm 2 http://ffdn.se/web/england-1/
Dr. Friedman's credentials are impeccable. As a former expert member of the CFS Advisory Committee under the authority of the U.S. Secretary of Health, Dr. Friedman has the knowledge, the expertise and the experience to comment on why Ampligen must be approved for ME/CFS treatments.
So far the questions are being pertinent from the FDA panel to the individuals representing Hemisphere Biopharma and the stakeholders who are there present as well. I had to take a quick break from watching the event and when I came back Dr. Bateman was answering a question on the issue of Cognitive Behavior Therapy (CBT). Her response (not verbatim) was that CBT is not a medical treatment but a coping mechanism tool for patients whose lives are in disarray due to the illness challenges.
If you are a ME/CFS patient or a loved one or a caregiver, please contact the FDA and let your voice be heard:
Here is the link to the calendar information on Dec 20, 2012 (today's meeting), which will end at 5 pm this afternoon.
ONE VOICE, ONE COMMUNITY, ONE CAUSE (TM).